Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak.
Identifieur interne : 000367 ( Main/Exploration ); précédent : 000366; suivant : 000368Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak.
Auteurs : Tao Zhang [République populaire de Chine] ; Qunfu Wu [République populaire de Chine] ; Zhigang Zhang [République populaire de Chine]Source :
- Current biology : CB [ 1879-0445 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Malaisie.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Chiroptera, Coronavirus Infections (virology), Disease Reservoirs (virology), Eutheria (virology), Genome, Viral, Malaysia, Pandemics, Phylogeny, Pneumonia, Viral (virology), Sequence Alignment, Spike Glycoprotein, Coronavirus (chemistry).
- MESH :
- chemical , chemistry : Spike Glycoprotein, Coronavirus.
- geographic : Malaysia.
- genetics : Betacoronavirus.
- isolation & purification : Betacoronavirus.
- virology : Coronavirus Infections, Disease Reservoirs, Eutheria, Pneumonia, Viral.
- Amino Acid Sequence, Animals, Chiroptera, Genome, Viral, Pandemics, Phylogeny, Sequence Alignment.
Abstract
An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) began in the city of Wuhan in China and has widely spread worldwide. Currently, it is vital to explore potential intermediate hosts of SARS-CoV-2 to control COVID-19 spread. Therefore, we reinvestigated published data from pangolin lung samples from which SARS-CoV-like CoVs were detected by Liu et al. [1]. We found genomic and evolutionary evidence of the occurrence of a SARS-CoV-2-like CoV (named Pangolin-CoV) in dead Malayan pangolins. Pangolin-CoV is 91.02% and 90.55% identical to SARS-CoV-2 and BatCoV RaTG13, respectively, at the whole-genome level. Aside from RaTG13, Pangolin-CoV is the most closely related CoV to SARS-CoV-2. The S1 protein of Pangolin-CoV is much more closely related to SARS-CoV-2 than to RaTG13. Five key amino acid residues involved in the interaction with human ACE2 are completely consistent between Pangolin-CoV and SARS-CoV-2, but four amino acid mutations are present in RaTG13. Both Pangolin-CoV and RaTG13 lost the putative furin recognition sequence motif at S1/S2 cleavage site that can be observed in the SARS-CoV-2. Conclusively, this study suggests that pangolin species are a natural reservoir of SARS-CoV-2-like CoVs.
DOI: 10.1016/j.cub.2020.03.022
PubMed: 32197085
Affiliations:
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Le document en format XML
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Currently, it is vital to explore potential intermediate hosts of SARS-CoV-2 to control COVID-19 spread. Therefore, we reinvestigated published data from pangolin lung samples from which SARS-CoV-like CoVs were detected by Liu et al. [1]. We found genomic and evolutionary evidence of the occurrence of a SARS-CoV-2-like CoV (named Pangolin-CoV) in dead Malayan pangolins. Pangolin-CoV is 91.02% and 90.55% identical to SARS-CoV-2 and BatCoV RaTG13, respectively, at the whole-genome level. Aside from RaTG13, Pangolin-CoV is the most closely related CoV to SARS-CoV-2. The S1 protein of Pangolin-CoV is much more closely related to SARS-CoV-2 than to RaTG13. Five key amino acid residues involved in the interaction with human ACE2 are completely consistent between Pangolin-CoV and SARS-CoV-2, but four amino acid mutations are present in RaTG13. Both Pangolin-CoV and RaTG13 lost the putative furin recognition sequence motif at S1/S2 cleavage site that can be observed in the SARS-CoV-2. Conclusively, this study suggests that pangolin species are a natural reservoir of SARS-CoV-2-like CoVs.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Tao" sort="Zhang, Tao" uniqKey="Zhang T" first="Tao" last="Zhang">Tao Zhang</name></noRegion><name sortKey="Wu, Qunfu" sort="Wu, Qunfu" uniqKey="Wu Q" first="Qunfu" last="Wu">Qunfu Wu</name><name sortKey="Zhang, Zhigang" sort="Zhang, Zhigang" uniqKey="Zhang Z" first="Zhigang" last="Zhang">Zhigang Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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